COMPANY

Management

Leadership

Ryo Kubota, MD, PhD

Chairman, President and Chief Executive Officer

Prior to founding Acucela in 2002, Dr. Kubota worked in the ophthalmology field, including serving as a faculty member at Keio University and at the University of Washington School of Medicine. Dr. Kubota holds an MD and a PhD in medicine from Keio University. There, he discovered the glaucoma gene, myocilin, a discovery that earned him the Suda Award for his contribution to the field of neurodegenerative retinal disease. He was board certified in ophthalmology by the Japanese Ophthalmological Society in 1996 and is a member of the American Academy of Ophthalmology, the Association for Research in Vision and Ophthalmology, the Japanese Ophthalmology Society, Keio Medical Society, the American Chamber of Commerce in Japan, and the America-Japan Society, Inc. Since 2008, Dr. Kubota has been a director of the Japan-America Society of the State of Washington. He was appointed as Foresight Advisory Group Member, Department of Pharmacology, Case Western Reserve University in 2012. In 2014, Dr. Kubota was appointed to the National Bureau of Asian Research Board of Directors, and a visiting professor at School of Medicine, Keio University. Since 2015, he has been an Advisory member for The Japanese Association of Medical University Network of Technology Transfer.

John Gebhart, MBA

Chief Financial Officer; Treasurer and Secretary

Mr. Gebhart joined Acucela in May 2015. Prior to that, from 2012 to 2015, he was Chief Financial Officer for Qliance Medical Management Inc., a leader in direct primary care services, where he led the company's financial and operations functions during a period of significant growth. From 2004 through 2012 he operated an independent consultancy providing project management and interim executive services to a variety of health services and technology companies including Remote Medical International, Ventripoint, PhysioSonics, Carena, Clarity Health, Nexcura, and DS-IQ. Mr. Gebhart has worked in emerging health and technology companies for more than 30 years in the roles of CFO, COO, and CEO. He began his career as a CPA with Ernst & Young and received his MBA from Pepperdine University in Malibu, CA.

Board of Directors

Ryo Kubota, MD, PhD

Representative Executive Officer, Chairman, President and Chief Executive Officer, Kubota Pharmaceutical Holdings Co., Ltd.

Chairman, President and Chief Executive Officer, Acucela Inc.

Shintaro Asako

Chief Financial Officer, DeNA Co., Ltd.

Shiro Mita, PhD

President and Chief Executive Officer, M's Science Corporation

Eisaku Nakamura

Corporate Auditor, Koinobori Associates Inc.

Robert Takeuchi

President, RT Consulting, Inc.

Advisory Board

David G. Birch, PhD

Research Director, Retina Foundation of the Southwest, Director of the Rose-Silverthorne Retinal Degenerations Laboratory, Dallas

Karl G. Csaky, MD, PhD

T. Boone Pickens Senior Scientist, Director, Harrington Molecular Laboratory, Member, Texas Retina Associates

Pravin U. Dugel, MD

Managing Partner, Retinal Consultants of Arizona

Dean Eliott, MD

Co-Director, Mass Eye & Ear, Vitrectomy Course, Massachusetts Eye and Ear Infirmary

Jeffrey S. Heier, MD

Vitreoretinal Specialist, Ophthalmic Consultants of Boston

Frank G. Holz, MD

Chairman & Professor of the Department of Ophthalmology, University of Bonn, Germany

Anne S. Lindblad, PhD

Executive Vice President, The EMMES Corporation

Carl D. Regillo, MD, FACS

Director, Retina Service, Wills Eye Institute-Mid-Atlantic Retina; Professor, Ophthalmology, Thomas Jefferson University School of Medicine

Philip J. Rosenfeld, MD, PhD

Professor, Bascom Palmer Eye Institute University of Miami Miller School of Medicine, and Bascom Palmer Eye Institute Palm Beach Gardens University of Miami Miller School of Medicine

Gaurav K. Shah, MD, PhD

Professor of Clinical Ophthalmology & Visual Sciences; Director of Vitreoretinal Fellowship Program, Washington University School of Medicine

Michael A. Singer, MD

Vitreoretinal Surgeon and Managing Partner, Medical Center Ophthalmology Associates; Clinical Assistant Professor, University of Texas Health Center

Janet S. Sunness, MD

Medical Director of Hoover Rehabilitation Services for Low Vision and Blindness, Greater Baltimore Medical Center

Kang Zhang, MD, PhD

Professor of Ophthalmology & Human Genetics, Shiley Eye Center, University of California San Diego

Eberhart Zrenner, MD

Professor, Department of Ophthalmology, Director of the Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Germany